2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Neuropeptide Y Receptor

Neuropeptide Y Receptor

NPY receptor

Neuropeptide Y Receptor

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Neuropeptide Y receptors belong G protein-coupled receptor superfamily and comprise various subtypes. There are currently five cloned NPY receptor subtypes in mammals, termed Y1, Y2, Y4, Y5, and Y6. Neuropeptide Y receptors mediate a variety of physiological responses including feeding and vasoconstriction.

Subtypes Y1, Y2, Y4 and Y5 are expressed in humans. They are present mainly in the central and peripheral nervous systems as well as other tissues, such as the cardiovascular system. Their physiologic ligands are the neurotransmitter Neuropeptide Y and the 2 hormones peptide YY (PYY) and pancreatic polypeptide (PP).

Neuropeptide Y and its receptors regulate important biological and pathophysiological functions, such as blood pressure, neuroendocrine secretions, seizures, neuronal excitability and neuroplasticity.

Neuropeptide Y Receptor Isoform Specific Products:

Neuropeptide Y Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P5063
    Galanin-Like Peptide (human)
    Galanin-Like Peptide (human) is a 60 amino acid neuropeptide. Galanin-Like Peptide (human) plays an important role in the regulation of feeding, body weight and energy metabolism.
    Galanin-Like Peptide (human)
  • HY-P1321A
    GR231118 TFA
    		Antagonist
    GR231118 TFA, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide YY receptor with a pKi of 10.4. GR231118 a potent agonist at the human neuropeptide YY4 receptor (pEC50=8.6; pKi=9.6) and a weak agonist at the human and rat neuropeptide Y Y2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide YY6 receptor (pKi= 8.8).
    GR231118 TFA
  • HY-P1128A
    Galanin (swine) (TFA)
    		Agonist
    Galanin (swine) TFA, a neuropeptide, consists of 29 amino acids and contains a C-terminal amidated glycine. Galanin (swine) inhibits basal and stimulated insulin secretion both in vivo and in vitro under a variety of experimental conditions. Galanin (swine) TFA is a galanin receptor agonist with pKis of 9.63, 9.49, 9.02, 8.98, 8.01 and 8.14 at human GAL1, rat GAL1, human GAL2, rat GAL2, human GAL3 and rat GAL3 respectively.
    Galanin (swine) (TFA)
  • HY-118198
    NPY Y2 antagonist 1
    		Antagonist
    NPY Y2 antagonist 1 (compound 36) is a pyridine-type, selective neuropeptide Y receptor (NPY) Y2 antagonist.
    NPY Y2 antagonist 1
  • HY-RS09515
    Npy2r Mouse Pre-designed siRNA Set A
    		Inhibitor

    Npy2r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Npy2r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Npy2r Mouse Pre-designed siRNA Set A
    Npy2r Mouse Pre-designed siRNA Set A
  • HY-107727
    BMS-193885 L-Lactic acid
    		Antagonist
    BMS-193885 (L-Lactic acid) is a potent, selective, and brain-penetrant neuropeptide Y1 receptor antagonist. BMS-193885 has a Ki value of 3.3 nM for the neuropeptide Y1 receptor, competitively acts on the neuropeptide Y binding site, and can reduce food intake and body weight through central Y1 inhibition.
    BMS-193885 L-Lactic acid
  • HY-P1322A
    [D-Trp34]-Neuropeptide Y TFA
    		Agonist
    [D-Trp34]-Neuropeptide Y TFA is a potent and selective neuropeptide Y (NPY) Y5 receptor agonist. [D-Trp34]-Neuropeptide Y TFA is a significantly less potent agonist at the NPY Y1, Y2, Y4, and y6 receptors. [D-Trp34]-Neuropeptide Y TFA markedly increases food intake in rats.
    [D-Trp34]-Neuropeptide Y TFA
  • HY-107725A
    BIBO3304 diTFA
    		Inhibitor
    BIBO3304 (diTFA) is an orally effective and selective neuropeptide Y (NPY) Y1 receptor antagonist. BIBO3304 (diTFA) has a high affinity for both human and rat Y1 receptors, with IC50 values of 0.38 and 0.72 nM, respectively. BIBO3304 (diTFA) promotes bone-tendon healing through the Wnt/β-catenin signaling pathway.
    BIBO3304 diTFA
  • HY-122021
    J-115814
    		Antagonist
    J-115814 is a potent and selective neuropeptide Y1 antagonist with Ki values of 1.4, 1.8, 1.9, >10000, 620, 6000, >10000 nM for hY1, rY1, mY1, hY2, hY4, hY5, mY6, respectively. J-115814 inhibits feeding behaviors.
    J-115814
  • HY-139799
    Sch 202596
    		Antagonist
    Sch 202596 is a non-peptide antagonist of the galanin receptor subtype GalR1. Sch 202596 blocks the action of galanin by binding to GalR1, thereby reducing food intake. Sch 202596 can be used in the study of obesity and related eating disorders.
    Sch 202596
  • HY-156922
    NPY-5 receptor antagonist-1
    		Antagonist 99.86%
    NPY-5 receptor antagonist-1 (Example 57) is a NPY-5 receptor antagonist (Ki: < 1 μM). NPY-5 receptor antagonist-1 can be used for research of obesity, feeding disorders, as well as other neurological diseases.
    NPY-5 receptor antagonist-1
  • HY-U00335
    FR252384
    		Antagonist
    FR252384 is a neuropeptide Y-Y5 receptor antagonist, with an IC50 of 2.3 nM.
    FR252384
Cat. No. Product Name / Synonyms Application Reactivity
Neuropeptide Y Receptor Isoform Comparison

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